Liu Gui-Dong, Ding Jian-Qing, Xiao Qin, Chen Sheng-Di
Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai 200025, China.
Neurosci Bull. 2009 Jun;25(3):161-4. doi: 10.1007/s12264-009-0120-3.
The immunocytes microglia in the central nervous system (CNS) were reported to play a crucial role in neurodegeneration. As a member of P2 receptors family, purinoceptor P2Y6 has attracted much attention recently. Previous studies showed that purinoceptor P2Y6 mainly contributed to microglia activation and their later phagocytosis in CNS, while in immune system, it participated in the secretion of interleukin (IL)-8 from monocytes and macrocytes. So there raises a question: whether purinoceptor P2Y6 also takes part in neuroinflammation? Thus, this review mainly concerns about the properties and roles of purinoceptor P2Y6, including (1) structure of purinoceptor P2Y6; (2) distribution and properties of purinoceptor P2Y6; (3) relationships between purinoceptor P2Y6 and microglia; (4) relationships between purinoceptor P2Y6 and immunoinflammation. Itos proposed that purinoceptor P2Y6 may play a role in neuroinflammation in CNS, although further research is still required.
据报道，中枢神经系统（CNS）中的免疫细胞小胶质细胞在神经退行性变中起关键作用。作为P2受体家族的一员，嘌呤受体P2Y6最近备受关注。先前的研究表明，嘌呤受体P2Y6主要促成中枢神经系统中小胶质细胞的激活及其随后的吞噬作用，而在免疫系统中，它参与单核细胞和巨噬细胞分泌白细胞介素（IL）-8。因此，出现了一个问题：嘌呤受体P2Y6是否也参与神经炎症？因此，本综述主要关注嘌呤受体P2Y6的特性和作用，包括（1）嘌呤受体P2Y6的结构；（2）嘌呤受体P2Y6的分布和特性；（3）嘌呤受体P2Y6与小胶质细胞的关系；（4）嘌呤受体P2Y6与免疫炎症的关系。伊托斯提出，嘌呤受体P2Y6可能在中枢神经系统的神经炎症中起作用，尽管仍需要进一步研究。
