脆性组氨酸三联体（FHIT）基因及其在胆囊癌进展中与p53蛋白表达的关联。
Fragile histidine triad (FHIT) gene and its association with p53 protein expression in the progression of gall bladder cancer.
作者信息
Priya T Padma, Kapoor V K, Krishnani Narendra, Agrawal Vinita, Agarwal Suraksha
机构信息
Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, UP, India.
出版信息
Cancer Invest. 2009 Aug;27(7):764-73. doi: 10.1080/07357900802711304.
OBJECTIVE
Present study deals with LOH and MSI in FHIT gene and p53 expression in GBC, CC, XGC, and normal GB to elucidate the role of FHIT gene in gall bladder cancer.
METHODS
Five microsatellite markers D3S1217, D3S1300, D3S1313, D3S1600, and D3S2757, were selected.
RESULTS
Among GBC cases the frequency of MSI-H and LOH was 17.5% and 27.5%, respectively. Significant difference was found between GBC and normal GB (p = .02), and GBC and CC groups (p= .002) when LOH was compared.
CONCLUSIONS
Our results suggested CC might act as a preinvasive stage in the pathogenesis of GBC.
目的
本研究探讨胆囊癌（GBC）、胆囊息肉（CC）、胆囊腺肌增生症（XGC）及正常胆囊组织中脆性组氨酸三联体（FHIT）基因的杂合性缺失（LOH）和微卫星不稳定性（MSI）以及p53蛋白的表达情况，以阐明FHIT基因在胆囊癌发生中的作用。
方法
选取5个微卫星标记，分别为D3S1217、D3S1300、D3S1313、D3S1600和D3S2757。
结果
在胆囊癌病例中，微卫星高度不稳定（MSI-H）和杂合性缺失（LOH）的发生率分别为17.5%和27.5%。比较LOH时，胆囊癌与正常胆囊组织之间（p = .02）以及胆囊癌与胆囊息肉组之间（p = .002）存在显著差异。
结论
我们的结果提示胆囊息肉可能在胆囊癌的发病机制中作为癌前阶段。
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