Lovejoy David A, Rotzinger Susan, Barsyte-Lovejoy Dalia
Department of Cell and Systems Biology, University of Toronto, Toronto, Canada.
Ann N Y Acad Sci. 2009 Apr;1163:215-20. doi: 10.1111/j.1749-6632.2008.03629.x.
In chordates, the corticotropin-releasing factor (CRF) family of peptides consists of four paralogous lineages that include CRF, urocortin/urotensin-I, urocortin 2, and urocortin 3. Related to the CRF peptide family is the diuretic hormone family found in insects. This family consists of a number of paralogous lineages within the Insecta. The teneurin C-terminal-associated peptides (TCAP) are a recently described family of peptides with evolutionary origins around the same time as the CRF family. This family consists of four independent lineages in chordates that are orthologous to peptides in the Insecta. Like CRF, the peptides are 40 or 41 amino acids in length and share about 20% sequence identity to the CRF family members. Each of the four TCAP peptides is encoded by an exon that is closely associated with the teneurin gene. Recent studies indicate that TCAP can block CRF-mediated c-fos expression in the brain and modulate CRF-mediated behaviors. Thus, the TCAP family may act, in part, to modulate the physiological actions of the CRF family.
在脊索动物中，促肾上腺皮质激素释放因子（CRF）肽家族由四个旁系同源谱系组成，包括CRF、尿皮质素/尾加压素-I、尿皮质素2和尿皮质素3。与CRF肽家族相关的是在昆虫中发现的利尿激素家族。该家族由昆虫纲内的多个旁系同源谱系组成。腱蛋白C末端相关肽（TCAP）是最近描述的一个肽家族，其进化起源与CRF家族大致相同。该家族在脊索动物中由四个独立的谱系组成，与昆虫中的肽是直系同源的。与CRF一样，这些肽长度为40或41个氨基酸，与CRF家族成员的序列同一性约为20%。四个TCAP肽中的每一个都由一个与腱蛋白基因紧密相关的外显子编码。最近的研究表明，TCAP可以阻断大脑中CRF介导的c-fos表达，并调节CRF介导的行为。因此，TCAP家族可能部分起到调节CRF家族生理作用的作用。
