Guerriero Giulia, Roselli Charles E, Ciarcia Gaetano
Department of Biological Sciences, Federico II University, Naples, Italy.
Ann N Y Acad Sci. 2009 Apr;1163:407-9. doi: 10.1111/j.1749-6632.2009.04438.x.
We report the presence of a progesterone receptor (PR) in the brain of the female amphibian Rana esculenta and changes in the levels of this PR during the gonadal recovery phase in relation to different circulating steroid levels and steroid treatment. The highest level of the PR in the nuclear brain extract corresponded to a low level of plasma progesterone and occurred when vitellogenin synthesis was at a minimum. The lowest level was found during follicular growth, concomitant with increased plasma 17beta-estradiol and progesterone levels. The PR levels were significantly higher in ovariectomized female R. esculenta than in intact and sham-operated female frogs. Treatment with 17beta-estradiol and progesterone downregulated the frog brain PR, indicating that a possible progesterone-receptor interaction is involved in the modulation of vitellogenin.
我们报告了雌性两栖动物食用蛙（Rana esculenta）大脑中存在孕酮受体（PR），以及在性腺恢复阶段该PR水平的变化与不同循环类固醇水平和类固醇处理的关系。核脑提取物中PR的最高水平对应于血浆孕酮的低水平，且发生在卵黄蛋白原合成最低时。最低水平是在卵泡生长期间发现的，同时血浆17β-雌二醇和孕酮水平升高。去卵巢的雌性食用蛙的PR水平显著高于完整和假手术的雌性蛙。用17β-雌二醇和孕酮处理可下调蛙脑PR，表明孕酮-受体之间可能的相互作用参与了卵黄蛋白原的调节。
