Mikler J, Banovcin P, Jesenak M, Hamzikova J, Statelova D
Department of Pediatrics, Jessenius School of Medicine, Comenius University in Bratislava, University hospital in Martin, Martin, Slovak Republic.
Toxicol Ind Health. 2009 Mar;25(2):137-40. doi: 10.1177/0748233709104759.
Severe acute lead intoxications are rare and are associated with accidental or purposeful ingestion. There were only few cases of severe to fatal poisonings reported in literature in children. We report a case of acute lead intoxication in a child with extremely high lead blood level of 20.4 micromol/L (422.7 microg/dL), who was treated with chelation and in whom significant organ dysfunction did not develop. Documented significant high level above 3.37 micromol/L (corresponding to 70 microg/dL) in this patient persisted for approximately 24 h. Adequate, single or combined chelatation therapy in early phase of acute lead poisoning is essential for the further patient's outcome.
严重急性铅中毒较为罕见，与意外或故意摄入有关。文献中报道的儿童严重至致命中毒病例较少。我们报告一例儿童急性铅中毒病例，其血铅水平极高，达20.4微摩尔/升（422.7微克/分升），经螯合治疗，未出现明显器官功能障碍。该患者血铅水平持续高于3.37微摩尔/升（相当于70微克/分升）达约24小时。在急性铅中毒早期进行充分的单一或联合螯合治疗对患者的后续转归至关重要。
