Wakasugi Daisuke, Kato Takashi, Gono Takahisa, Ito Eiichi, Nodera Hiroyuki, Kawaguchi Yasushi, Yamanaka Hisashi, Hara Masako
Department of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan.
Mod Rheumatol. 2009;19(4):437-40. doi: 10.1007/s10165-009-0180-2. Epub 2009 May 22.
Neurological involvement occurs in approximately 20% of patients with primary Sjögren's syndrome. Although neurological symptoms can affect the peripheral nervous system and the central nervous system, the most frequent symptom is polyneuropathy. Small fiber neuropathy (SFN) is a form of painful peripheral polyneuropathy that is common in patients with diabetic neuropathy, but may also occur in toxic, infectious, or immune-mediated neuropathy. We show here a patient with Sjögren's syndrome who developed SFN and was treated with intravenous immunoglobulin (IVIG) therapy, which was immediately and extremely effective. Because of the efficacy of IVIG therapy, we propose that direct immune-mediated mechanisms may be involved in the pathogenesis of SFN complicated by Sjögren's syndrome.
约20%的原发性干燥综合征患者会出现神经受累情况。虽然神经症状可影响周围神经系统和中枢神经系统，但最常见的症状是多发性神经病。小纤维神经病（SFN）是一种疼痛性周围多发性神经病，常见于糖尿病性神经病患者，但也可能发生于中毒性、感染性或免疫介导性神经病。我们在此展示了一名患有干燥综合征并发生SFN的患者，其接受了静脉注射免疫球蛋白（IVIG）治疗，该治疗立即且极其有效。由于IVIG治疗的有效性，我们提出直接免疫介导机制可能参与了干燥综合征并发SFN的发病过程。
