大鼠喉内肌与年龄相关的血流变化。

Age-related blood flow changes in the rat intrinsic laryngeal muscles.

作者信息

Lyon Michael J, Malmgren Leslie T

机构信息

Otolaryngology and Communication Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

出版信息

Acta Otolaryngol. 2010;130(1):145-9. doi: 10.3109/00016480902968078.

DOI:10.3109/00016480902968078

PMID:19459074

Abstract

CONCLUSIONS

These results indicate that a deceased laryngeal blood flow (BF) could be one contributing factor to age-related phonatory and airway dysfunction.

OBJECTIVE

Studies of non-laryngeal muscles suggest that decreased BF may contribute to an age-related decline in muscle performance. We hypothesized that there is an age-related BF decrease to the intrinsic laryngeal muscles.

MATERIALS AND METHODS

Intrinsic laryngeal muscle BF was measured in young (3-6 months old; n=11) and old (28-30 months old; n=21) male Fischer 344 rats during quiet respiration using the radiolabeled microsphere technique.

RESULTS

BF to the posterior cricoarytenoid (PCA) was very high even during this submaximal recruitment, consistent with its specialization for oxidative metabolism and fatigue resistance. The results demonstrated significant (p<0.05) age-related BF decreases in the thyroarytenoid (young, 163; old, 64 ml/min/100 g), cricothyroid (young, 104; old, 52 ml/min/100 g), and PCA (young, 404; old, 235 ml/min/100 g).

摘要

结论

这些结果表明，喉血流（BF）减少可能是与年龄相关的发声和气道功能障碍的一个促成因素。

目的

对非喉肌的研究表明，BF减少可能导致与年龄相关的肌肉性能下降。我们假设，喉内肌存在与年龄相关的BF减少。

材料与方法

采用放射性微球技术，在安静呼吸期间测量年轻（3 - 6个月龄；n = 11）和老年（28 - 30个月龄；n = 21）雄性Fischer 344大鼠的喉内肌BF。

结果

即使在这种次最大募集期间，环杓后肌（PCA）的BF也非常高，这与其对氧化代谢和抗疲劳的特化相一致。结果显示，甲杓肌（年轻组，163；老年组，64毫升/分钟/100克）、环甲肌（年轻组，104；老年组，52毫升/分钟/100克）和PCA（年轻组，404；老年组，235毫升/分钟/100克）的BF均出现了显著的（p < 0.05）与年龄相关的下降。