Smylie Michael, Claveau Joël, Alanen Kenneth, Taillefer Raymond, George Ralph, Wong Ralph, Mason Warren P
Cross Cancer Institute, Edmonton, AB, Canada.
J Cutan Med Surg. 2009 Mar-Apr;13(2):55-73. doi: 10.2310/7750.2008.08029.
Melanoma is a commonly occurring cancer in Canada, with an estimated age-standardized incidence of 10 to 13 per 100,000. An estimated 4,300 new cases were diagnosed, and there were 800 reported deaths in 2005.
The Canadian Expert Panel on Malignant Melanoma has developed best practices to improve the management of malignant melanoma. Sections include recommendations on primary diagnosis, dermatopathologic assessment, and reporting; use of preoperative lymphoscintigraphy and an intraoperative gamma probe to map and biopsy the sentinel lymph node; indications for surgical resection, sentinel node biopsy, and surgery for advance disease; use of interferon-alpha adjuvant therapy and treatment options for stage IV disease; and management of central nervous system metastases.
黑色素瘤是加拿大常见的癌症，估计年龄标准化发病率为每10万人中有10至13例。2005年估计有4300例新病例被诊断出来，并有800例报告死亡。
加拿大恶性黑色素瘤专家小组制定了最佳实践方法以改善恶性黑色素瘤的管理。内容包括关于初步诊断、皮肤病理评估及报告的建议；术前淋巴闪烁显像和术中γ探测器用于前哨淋巴结定位及活检的应用；手术切除、前哨淋巴结活检及晚期疾病手术的指征；α干扰素辅助治疗的应用及IV期疾病的治疗选择；以及中枢神经系统转移的管理。
