Pinto Marcia Da Silva, Ranilla Lena Galvez, Apostolidis Emmanouil, Lajolo Franco Maria, Genovese Maria Inés, Shetty Kalidas
Departamento de Alimentos e Nutrição Experimental, Faculdade de Ciencias Farmaceuticas, Universidade de São Paulo, São Paulo, Brazil.
J Med Food. 2009 Apr;12(2):278-91. doi: 10.1089/jmf.2008.0113.
Local food diversity and traditional crops are essential for cost-effective management of the global epidemic of type 2 diabetes and associated complications of hypertension. Water and 12% ethanol extracts of native Peruvian fruits such as Lucuma (Pouteria lucuma), Pacae (Inga feuille), Papayita arequipeña (Carica pubescens), Capuli (Prunus capuli), Aguaymanto (Physalis peruviana), and Algarrobo (Prosopis pallida) were evaluated for total phenolics, antioxidant activity based on 2, 2-diphenyl-1-picrylhydrazyl radical scavenging assay, and functionality such as in vitro inhibition of alpha-amylase, alpha-glucosidase, and angiotensin I-converting enzyme (ACE) relevant for potential management of hyperglycemia and hypertension linked to type 2 diabetes. The total phenolic content ranged from 3.2 (Aguaymanto) to 11.4 (Lucuma fruit) mg/g of sample dry weight. A significant positive correlation was found between total phenolic content and antioxidant activity for the ethanolic extracts. No phenolic compound was detected in Lucuma (fruit and powder) and Pacae. Aqueous extracts from Lucuma and Algarrobo had the highest alpha-glucosidase inhibitory activities. Papayita arequipeña and Algarrobo had significant ACE inhibitory activities reflecting antihypertensive potential. These in vitro results point to the excellent potential of Peruvian fruits for food-based strategies for complementing effective antidiabetes and antihypertension solutions based on further animal and clinical studies.
当地食物多样性和传统作物对于以具有成本效益的方式管理全球2型糖尿病流行及相关高血压并发症至关重要。对秘鲁本土水果如蛋黄果（桃榄属蛋黄果）、帕卡（洋紫荆属）、阿雷基帕番木瓜（番木瓜）、卡普利（李属卡普利）、阿瓜曼托（灯笼果）和牧豆树（牧豆树属苍白牧豆树）的水提取物和12%乙醇提取物进行了总酚含量、基于2,2-二苯基-1-苦基肼自由基清除试验的抗氧化活性以及体外抑制α-淀粉酶、α-葡萄糖苷酶和血管紧张素I转换酶（ACE）等与2型糖尿病相关的高血糖和高血压潜在管理相关功能的评估。总酚含量范围为每克样品干重3.2（阿瓜曼托）至11.4（蛋黄果）毫克。乙醇提取物的总酚含量与抗氧化活性之间存在显著正相关。在蛋黄果（果实和粉末）和帕卡中未检测到酚类化合物。蛋黄果和牧豆树的水提取物具有最高的α-葡萄糖苷酶抑制活性。阿雷基帕番木瓜和牧豆树具有显著的ACE抑制活性，反映出其降压潜力。这些体外研究结果表明，基于进一步的动物和临床研究，秘鲁水果在基于食物的策略中具有巨大潜力，可补充有效的抗糖尿病和抗高血压解决方案。
