黏细菌——用于生产生物活性次级代谢产物的“微生物工厂”。
Myxobacteria--'microbial factories' for the production of bioactive secondary metabolites.
作者信息
Wenzel Silke C, Müller Rolf
机构信息
Pharmaceutical Biotechnology, Saarland University, Saarbrücken, Germany.
出版信息
Mol Biosyst. 2009 Jun;5(6):567-74. doi: 10.1039/b901287g. Epub 2009 Apr 23.
DOI:10.1039/b901287g
PMID:19462013
Abstract
In this article, we briefly review the potential of myxobacteria as 'natural product factories' by highlighting results from the recently sequenced myxobacterial model strain Myxococcus xanthus. We will focus on the production of polyketides, non-ribosomally-made peptides, and their hybrids, and discuss the evaluation of biosynthetic potential using genome-based methods, as well as biosynthetic process engineering.
摘要
在本文中，我们通过强调近期测序的粘细菌模式菌株黄色粘球菌的研究结果，简要回顾了粘细菌作为“天然产物工厂”的潜力。我们将重点关注聚酮化合物、非核糖体合成肽及其杂合物的生产，并讨论使用基于基因组的方法评估生物合成潜力以及生物合成过程工程。
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