通过固相肽合成制备C端肽α-酮酸的通用策略。
A general strategy for the preparation of C-terminal peptide alpha-ketoacids by solid phase peptide synthesis.
作者信息
Ju Lei, Bode Jeffrey W
机构信息
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
出版信息
Org Biomol Chem. 2009 Jun 7;7(11):2259-64. doi: 10.1039/b901198f. Epub 2009 Apr 2.
Abstract
A new cyanosulfur-ylide based linker makes possible the synthesis of C-terminal peptide alpha-ketoacids by solid phase synthesis. The preparation of the requisite linker and its application to a variety of C-terminal peptide alpha-ketoacids with unprotected side chains is reported.
摘要
一种基于氰基硫叶立德的新型连接子使得通过固相合成法合成C端肽α-酮酸成为可能。本文报道了所需连接子的制备及其在多种具有未保护侧链的C端肽α-酮酸中的应用。
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