基于胆汁酸的聚氨基羧酸盐缀合物作为靶向抗肿瘤剂。
Bile acid-based polyaminocarboxylate conjugates as targeted antitumor agents.
作者信息
Chong Hyun-Soon, Song Hyun A, Ma Xiang, Lim Sooyoun, Sun Xiang, Mhaske Santosh B
机构信息
Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, Chicago, IL, USA.
出版信息
Chem Commun (Camb). 2009 Jun 7(21):3011-3. doi: 10.1039/b823000e. Epub 2009 May 1.
DOI:10.1039/b823000e
PMID:19462070
Abstract
Bile acid-polyaminocarboxylate conjugates containing NE3TA, a potential iron chelator displayed significant cytotoxicities in both HeLa and HT29 colon cancer cells, and cholic acid-NE3TA attached to an organic fluorophore was shown to enter the HT29 cancer cells.
摘要
含有潜在铁螯合剂NE3TA的胆汁酸-聚氨基羧酸盐共轭物在HeLa细胞和HT29结肠癌细胞中均表现出显著的细胞毒性，并且连接有机荧光团的胆酸-NE3TA被证明可进入HT29癌细胞。
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