利用从细胞指数富集的配体系统进化而来的适配体构建一个分子递送平台。

Using aptamers evolved from cell-SELEX to engineer a molecular delivery platform.

作者信息

Mallikaratchy Prabodhika, Liu Haipeng, Huang Yu Fen, Wang Hui, Lopez-Colon Dalia, Tan Weihong

机构信息

Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA.

出版信息

Chem Commun (Camb). 2009 Jun 7(21):3056-8. doi: 10.1039/b823258j. Epub 2009 Apr 9.

DOI:10.1039/b823258j

PMID:19462085

Abstract

We report a chemically modified construct of the Sgc8 aptamer, selected against CEM cells, conjugated to an activator platform for stimulated release of molecules at the tumor surface using DNA template assisted functional group transfer reactions (DTGTR).

摘要

我们报告了一种针对CEM细胞筛选出的Sgc8适体的化学修饰构建体，该构建体与一个激活剂平台偶联，利用DNA模板辅助官能团转移反应（DTGTR）在肿瘤表面刺激分子释放。