Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Biology, Hunan University, Changsha 410082, PR China.
Chem Commun (Camb). 2012 Nov 4;48(85):10472-80. doi: 10.1039/c2cc35042d.
The last two decades have witnessed the development and application of nucleic acid aptamers in a variety of fields, including target analysis, disease therapy, and molecular and cellular engineering. The efficient and widely applicable aptamer selection, reproducible chemical synthesis and modification, generally impressive target binding selectivity and affinity, relatively rapid tissue penetration, low immunogenicity, and rapid systemic clearance make aptamers ideal recognition elements for use as therapeutics or for in vivo delivery of therapeutics. In this feature article, we discuss the development and biomedical application of nucleic acid aptamers, with emphasis on cancer cell aptamer isolation, targeted cancer therapy, oncology biomarker identification and drug discovery.
过去二十年见证了核酸适体在多个领域的发展和应用，包括目标分析、疾病治疗以及分子和细胞工程。适体具有高效且广泛适用的筛选方法、可重复的化学合成和修饰、通常令人印象深刻的靶标结合选择性和亲和力、相对较快的组织渗透能力、低免疫原性和快速的全身清除率，这些特点使得适体成为治疗药物或体内递药的理想识别元件。在这篇专题文章中，我们讨论了核酸适体的开发和生物医学应用，重点介绍了癌细胞适体的分离、靶向癌症治疗、肿瘤生物标志物的鉴定和药物发现。
