[大鼠肝脏和肝癌27细胞核膜及细胞核的磷脂组成]

[Phospholipid composition of nuclear membranes and cell nuclei of rat liver and hepatoma 27].

作者信息

Lemenovskaia A F, Koen Ia M, Perevoshchikova K A, Zbarskiĭ I B, Diatlovitskaia E V

出版信息

Biokhimiia. 1976 Jul;41(6):1000-3.

PMID:194623

Abstract

Phospholipid composition of nuclei and nuclear membranes from rat liver and hepatoma-27 were investigated. Hepatoma nuclei and nuclear membranes were found to contain cardiolipin which was absent in the same fractions of rat liver. In the nuclei and nuclear membranes of hepatoma the content of sphingomyelin was higher and that of lecithin is lower than in the corresponding subcellular fractions of rat liver. The content of acid phospholipids was much higher in hepatoma nuclear membranes than those of the normal liver. The data obtained show that the general trend of lipid dedifferentiation which earlier was demonstrated for various membranes of different tumor cells is observed also in the case of nuclear membranes.

摘要

对大鼠肝脏和肝癌-27细胞核及核膜的磷脂组成进行了研究。发现肝癌细胞核及核膜含有心磷脂，而在大鼠肝脏的相同组分中不存在心磷脂。与大鼠肝脏相应的亚细胞组分相比，肝癌细胞核及核膜中鞘磷脂含量较高，卵磷脂含量较低。肝癌核膜中酸性磷脂的含量比正常肝脏的高得多。所获得的数据表明，脂质去分化的总体趋势，此前在不同肿瘤细胞的各种膜中已得到证实，在核膜的情况下也观察到了。