Kepka Lucyna
Zakład Teleradioterapii Centrum Onkologii - Instytutu im. Marii Skłodowskiej-Curie w Warszawie, 02-781 Warszawa.
Pneumonol Alergol Pol. 2009;77(2):166-72.
Patients aged 70 years and older accounted for 42% of all lung cancer deaths in Poland in 2005. Although the incidence of lung cancer in elderly people is growing in Poland, like in other developed countries, the standards of treatment for this subset of population are not well established. Prospective elderly-specific trials concerning curative treatment are lacking. The results from prospective trials including elderly participants show similar effectiveness as in younger population at the expense of higher toxicity. Selection bias may limit the ability to generalize results of clinical trials to the entire population of elderly people. Methods of curative treatment (surgery, radiotherapy, chemotherapy as adjuvant for non-small cell lung cancer and basic treatment for limited-stage small cell lung cancer) are discussed. Some treatment options and modifications of standard strategies which are particularly promising in elderly patients, as VADS surgery, stereotactic radiotherapy or abbreviated treatment for SCLC, are presented.
2005年,70岁及以上的患者占波兰所有肺癌死亡人数的42%。尽管与其他发达国家一样,波兰老年人肺癌的发病率在上升,但针对这一特定人群的治疗标准尚未确立。缺乏关于根治性治疗的前瞻性老年特异性试验。纳入老年参与者的前瞻性试验结果显示,其有效性与年轻人群相似,但毒性更高。选择偏倚可能会限制将临床试验结果推广至全体老年人群的能力。本文讨论了根治性治疗方法(手术、放疗、作为非小细胞肺癌辅助治疗的化疗以及局限期小细胞肺癌的基础治疗)。还介绍了一些在老年患者中特别有前景的治疗选择和标准策略的调整,如VADS手术、立体定向放疗或小细胞肺癌的简化治疗。