Ma Renjun, Hasan M Tariqul, Sneddon Gary
Department of Mathematics and Statistics, University of New Brunswick, Fredericton, NB, Canada E3B 5A3.
Stat Med. 2009 Aug 15;28(18):2356-69. doi: 10.1002/sim.3619.
In medical and health studies, heterogeneities in clustered count data have been traditionally modeled by positive random effects in Poisson mixed models; however, excessive zeros often occur in clustered medical and health count data. In this paper, we consider a three-level random effects zero-inflated Poisson model for health-care utilization data where data are clustered by both subjects and families. To accommodate zero and positive components in the count response compatibly, we model the subject level random effects by a compound Poisson distribution. Our model displays a variance components decomposition which clearly reflects the hierarchical structure of clustered data. A quasi-likelihood approach has been developed in the estimation of our model. We illustrate the method with analysis of the health-care utilization data. The performance of our method is also evaluated through simulation studies.
在医学与健康研究中,聚类计数数据中的异质性传统上通过泊松混合模型中的正随机效应进行建模;然而,聚类的医学与健康计数数据中经常出现过多的零值。在本文中,我们针对医疗保健利用数据考虑一种三级随机效应零膨胀泊松模型,其中数据按个体和家庭进行聚类。为了兼容地处理计数响应中的零值和正值成分,我们通过复合泊松分布对个体水平的随机效应进行建模。我们的模型展示了一种方差成分分解,清晰地反映了聚类数据的层次结构。在我们模型的估计中开发了一种拟似然方法。我们通过对医疗保健利用数据的分析来说明该方法。我们还通过模拟研究评估了我们方法的性能。