Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, 13201 Bruce B. Downs, MDC 56, Tampa, FL 33612, USA.
Math Biosci. 2010 Apr;224(2):126-30. doi: 10.1016/j.mbs.2010.01.004. Epub 2010 Jan 18.
This paper presents new methods, using a Bayesian approach, for analyzing longitudinal count data with excess zeros and nonlinear effects of continuously valued covariates. In longitudinal count data there are many problems that can make the use of a zero-inflated Poisson (ZIP) model ineffective. These problems are unobserved heterogeneity and nonlinear effects of continuously valued covariates. Our proposed semiparametric model can simultaneously handle these problems in a unified framework. The framework accounts for heterogeneity by incorporating random effects and has two components. The parametric component of the model which deals with the linear effects of time invariant covariates and the non-parametric component which gives an arbitrary smooth function to model the effect of time or time-varying covariates on the logarithm of mean count. The proposed methods are illustrated by analyzing longitudinal count data on the assessment of an efficacy of pesticides in controlling the reproduction of whitefly.
本文提出了新的方法,使用贝叶斯方法,分析具有过剩零和连续值协变量非线性效应的纵向计数数据。在纵向计数数据中,存在许多问题可能会使零膨胀泊松(ZIP)模型无效。这些问题是未观测的异质性和连续值协变量的非线性效应。我们提出的半参数模型可以在统一框架中同时处理这些问题。该框架通过纳入随机效应来考虑异质性,并且具有两个组件。模型的参数组件处理时间不变协变量的线性效应,非参数组件则为模型对平均计数对数的影响赋予任意平滑函数,以处理时间或时变协变量的效应。通过分析控制粉虱繁殖的杀虫剂功效的纵向计数数据,说明了所提出的方法。