Hirt S W, Schäfers H J, Wagner T O, Hamm M, Kotzerke J, Haverich A
Klinik für Thorax-, Herz- und Gefässchirurgie, Medizinische Hochschule Hannover.
Pneumologie. 1991 Sep;45(9):715-9.
Early attempts of single lung transplantation for end-stage chronic obstructive pulmonary disease mostly failed due to a ventilation-perfusion mismatch between the allograft and the contralateral native lung. We performed unilateral lung transplantation in a 39-year-old female with severe pulmonary emphysema and could demonstrate in a one year follow-up that the transplanted lung will be given preference for both--ventilation and perfusion in approximately the same ratio (80%/90%). With improvement of pulmonary preservation, individual adjustment of immunosuppression and detailed monitoring of the transplanted lung unilateral lung transplantation becomes a therapeutical option in patients with severe emphysema.
早期针对终末期慢性阻塞性肺疾病进行单肺移植的尝试大多因移植肺与对侧天然肺之间的通气-灌注不匹配而失败。我们为一名39岁的重度肺气肿女性患者进行了单肺移植，并在一年的随访中发现，移植肺在通气和灌注方面均获得了大致相同比例（80%/90%）的优先供应。随着肺保存技术的改进、免疫抑制的个体化调整以及对移植肺的详细监测，单肺移植成为重度肺气肿患者的一种治疗选择。
