新型纤溶酶FA-I对血栓形成及溶栓的作用
[Effect of a novel fibrinolytic enzyme FA-I on thrombosis and thrombolysis].
作者信息
Wang Gao-xue, Liang Chao-jun, Yao Jia-yun, Yuan Ju-lin, Wang Jian-fu
机构信息
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
出版信息
Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Mar;40(2):288-91.
OBJECTIVE
To study the effect of FA-I, a novel fibrinolytic enzyme isolated from the metabolite of Arthrobacter sp. DR-536, on thrombosis and thrombolysis in vivo.
METHODS
The anticoagulated blood model of mise were administered with FA-I orally. The venous thrombogenesis inhibition model of rats were administered with FA-I by intestinal route. The carotid thrombosis model of rabbits were given FA-I intravenously. The clotting time (CT), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), Euglobulin lysis time (ELT), fibrinogen (FIG) and hemorheology condition were analyzed.
RESULTS
FA-I prolonged the CT, PT, APTT and TT, and decreased ELT and FIG significantly (P < 0.05 or P < 0.01). FA-I also improved the hemorheology conditions in the rabbits.
CONCLUSION
Both intravenous injection and oral administration of FA-I are effective in thrombosis and thrombolysis. FA-I could become a pragmatic venoclysis thrombolytic drug or a peroral thrombolytic drug.
目的
研究从节杆菌属DR - 536代谢产物中分离得到的新型纤溶酶FA - I对体内血栓形成及溶栓的影响。
方法
给小鼠抗凝血液模型口服FA - I。给大鼠静脉血栓形成抑制模型经肠道给予FA - I。给家兔颈动脉血栓模型静脉注射FA - I。分析凝血时间（CT）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、优球蛋白溶解时间（ELT）、纤维蛋白原（FIG）及血液流变学状况。
结果
FA - I显著延长CT、PT、APTT和TT，并显著降低ELT和FIG（P < 0.05或P < 0.01）。FA - I还改善了家兔的血液流变学状况。
结论
静脉注射和口服FA - I对血栓形成及溶栓均有效。FA - I有望成为一种实用的静脉溶栓药物或口服溶栓药物。
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