Litvinenko L A
Probl Endokrinol (Mosk). 1991 May-Jun;37(3):6-8.
A study was made of changes in the activity of erythrocyte antioxidant enzymes (superoxide dismutase and catalase) with regard to the blood level of glucose in children with insulin dependent diabetes mellitus and in vitro. A total of 83 children aged 3 to 14 with insulin dependent diabetes mellitus and 10 healthy adults were investigated. Catalase activity did not change whereas superoxide dismutase activity in decompensation of disease was significantly lower than that in its compensation. Experiments in vitro revealed that glucose, added to erythrocytes of donors in the concentration of 20 mumol/l, caused a double decrease in the activity of both enzymes at 37 degrees C for 2 h as compared to control test values. Thus glucose was shown to be able to act as a modifier of enzymes, and the state of antioxidant protection of erythrocytes depended on its blood level.
对胰岛素依赖型糖尿病患儿红细胞抗氧化酶（超氧化物歧化酶和过氧化氢酶）活性的变化及其与血糖水平的关系进行了体内和体外研究。共调查了83名3至14岁的胰岛素依赖型糖尿病患儿和10名健康成年人。过氧化氢酶活性未发生变化，而疾病失代偿期的超氧化物歧化酶活性显著低于代偿期。体外实验表明，与对照测试值相比，向供体红细胞中添加浓度为20μmol/l的葡萄糖，在37℃下作用2小时，会使两种酶的活性双双下降。因此，葡萄糖被证明能够作为酶的调节剂，红细胞抗氧化保护状态取决于其血糖水平。
