Larson Melissa L, Venugopal Parameswaran
Section of Hemtology, Rush University Medical Center, 1725 West Harrison, Suite 809, Chicago, IL 60612, USA.
Expert Opin Pharmacother. 2009 Jun;10(8):1353-7. doi: 10.1517/14656560902997990.
Clofarabine is a rationally designed, second-generation deoxyadenosine analog that incorporates characteristics of two other purine analogs, fludarabine and cladribine. It has shown efficacy in hematologic malignancies such as acute lymphoblastic leukemia, acute myeloid leukemia and myelodysplastic syndrome. It has already been approved for use in pediatric acute lymphoblastic leukemia after two lines of previous therapy. Clinical trials have also shown clofarabine to have activity both as a single agent and in combination with other cytotoxic drugs in adult myeloid leukemia. This compound seems to have efficacy in older patients, as well as those with adverse cytogenetics.
氯法拉滨是一种经过合理设计的第二代脱氧腺苷类似物，它融合了另外两种嘌呤类似物氟达拉滨和克拉屈滨的特性。它在血液系统恶性肿瘤如急性淋巴细胞白血病、急性髓系白血病和骨髓增生异常综合征中已显示出疗效。在经过两线先前治疗后，它已被批准用于小儿急性淋巴细胞白血病。临床试验还表明，氯法拉滨在成人髓系白血病中作为单药以及与其他细胞毒性药物联合使用时均具有活性。这种化合物似乎对老年患者以及细胞遗传学不良的患者有效。
