Pastor-Nieto M A, Kilmurray L G, Requena L
Servicio de Dermatología, Hospital General Universitario de Guadalajara, Guadalajara, España.
Actas Dermosifiliogr. 2009 May;100(4):321-4.
Pigmented atypical fibroxanthoma is a rare variant of atypical fibroxanthoma and is characterized by extensive areas of hemorrhage, erythrophagocytosis, and hemosiderin accumulation in the cytoplasm of the neoplastic cells. It affects elderly individuals and presents as irregularly pigmented, dome-shaped nodules or plaques on areas of skin exposed to the sun. We present a case of pigmented atypical fibroxanthoma on the cheek of an 81-year-old man. Six years after excision of the lesion, the patient remains in complete remission, with no signs of residual tumor or metastasis. The 9 cases of pigmented atypical fibroxanthoma reported in the literature are reviewed, and the histopathological features and differential diagnosis are discussed.
色素性非典型纤维黄色瘤是非典型纤维黄色瘤的一种罕见变体，其特征是肿瘤细胞胞质内有广泛的出血区、红细胞吞噬现象和含铁血黄素积聚。它好发于老年人，表现为暴露于阳光下的皮肤部位出现不规则色素沉着的圆顶状结节或斑块。我们报告一例81岁男性脸颊部色素性非典型纤维黄色瘤病例。病变切除6年后，患者仍处于完全缓解状态，无残留肿瘤或转移迹象。本文回顾了文献报道的9例色素性非典型纤维黄色瘤病例，并讨论了其组织病理学特征及鉴别诊断。
