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完全性房室间隔缺损初次修复后的再次手术

Reoperations after initial repair of complete atrioventricular septal defect.

作者信息

Stulak John M, Burkhart Harold M, Dearani Joseph A, Schaff Hartzell V, Cetta Frank, Barnes Roxann D, Puga Francisco J

机构信息

Division of Cardiovascular Surgery, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

出版信息

Ann Thorac Surg. 2009 Jun;87(6):1872-7; discussion 1877-8. doi: 10.1016/j.athoracsur.2009.02.048.

Abstract

BACKGROUND

Excellent surgical results have been reported after repair of complete atrioventricular septal defects (CAVSD); however, 5% to 10% require reoperation. We examine causes leading to reoperation and evaluate long-term outcome.

METHODS

Between 1972 and 2007, 50 patients (26 male) underwent reoperation at our institution after initial repair of CAVSD (median interval, 15 months; range, 3 days to 29 years). Median age at first reoperation was 4.5 years (range, 53 days to 38 years). Indications for first reoperation included left atrioventricular valve (LAVV) regurgitation in 41 patients, subaortic stenosis in 5, and LAVV stenosis, residual atrial septal defect (ASD), pulmonary artery (PA) stenosis, and aortic coarctation in 1 each.

RESULTS

The first reoperation included LAVV repair in 21 patients and replacement in 21, modified Konno procedure in 3, septal myectomy in 2, and PA reconstruction, coarctation repair, and ASD re-repair in 1 each. After LAVV repair (n = 21) 5 patients required a second reoperation, and after LAVV replacement (n = 21) 6 patients required a second reoperation. Overall freedom from further reoperation after the first reoperation was 63%, 48%, and 42% at 5, 10, and 15 years, respectively. There were 2 early deaths (4%) after first reoperation, and none after subsequent reoperations. During late follow-up (median 10.7 years, maximum 30 years), actuarial overall survival was 91%, 91%, and 86% at 5, 10, and 15 years, respectively.

CONCLUSIONS

The most common indication for reoperation after CAVSD repair is LAVV regurgitation. LAVV re-repair offers good durability, and LAVV replacement does not preclude additional reoperations. Long-term survival is very good despite need for multiple reoperations in some.

摘要

背景

完全性房室间隔缺损(CAVSD)修复术后已报道有出色的手术效果;然而,5%至10%的患者需要再次手术。我们研究导致再次手术的原因并评估长期预后。

方法

1972年至2007年间,50例患者(26例男性)在我院初次修复CAVSD后接受了再次手术(中位间隔时间为15个月;范围为3天至29年)。首次再次手术时的中位年龄为4.5岁(范围为53天至38岁)。首次再次手术的指征包括41例患者存在左房室瓣(LAVV)反流,5例患者存在主动脉瓣下狭窄,1例患者分别存在LAVV狭窄、残余房间隔缺损(ASD)、肺动脉(PA)狭窄和主动脉缩窄。

结果

首次再次手术包括21例患者进行LAVV修复,21例患者进行置换,3例患者进行改良Konno手术,2例患者进行间隔心肌切除术,1例患者分别进行PA重建、缩窄修复和ASD再次修复。LAVV修复后(n = 21),5例患者需要进行第二次再次手术,LAVV置换后(n = 21),6例患者需要进行第二次再次手术。首次再次手术后5年、10年和15年无需进一步再次手术的总体自由度分别为63%、48%和42%。首次再次手术后有2例早期死亡(4%),后续再次手术后无死亡。在晚期随访(中位时间10.7年,最长30年)期间,5年、10年和15年的精算总生存率分别为91%、91%和86%。

结论

CAVSD修复术后再次手术最常见的指征是LAVV反流。LAVV再次修复具有良好的耐久性,LAVV置换并不排除再次进行手术。尽管部分患者需要多次再次手术,但长期生存率非常高。

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