糖耐量不同个体间空腹血清胰岛素样生长因子结合蛋白-1（IGFBP-1）的生物学变异
Biological variation in fasting serum insulin-like growth factor binding protein-1 (IGFBP-1) among individuals with a varying glucose tolerance.
作者信息
Borai Anwar, Livingstone Callum, Mehta Shweta, Zarif Hawazen, Abdelaal Fatima, Ferns Gordon
机构信息
University of Surrey, Guildford, UK.
出版信息
Clin Biochem. 2009 Aug;42(12):1270-4. doi: 10.1016/j.clinbiochem.2009.05.005. Epub 2009 May 20.
OBJECTIVE
To evaluate the biological variation of serum insulin-like growth factor binding protein-1 (IGFBP-1) in individuals with different degrees of glucose tolerance.
RESEARCH DESIGN AND METHODS
IGFBP-1 was measured in 42 fasted subjects with: normal glucose tolerance (NGT=15), impaired fasting glucose (IFG=9), impaired glucose tolerance (IGT=9) and type 2 diabetics (DM=9). Short- and long-term reproducibility was determined for IGFBP-1.
RESULTS
The longer-term reproducibility (CV) of serum IGFBP-1 was 20.9%, 29.5%, 33.1% and 48.0% for subjects with NGT, IFG, IGT and DM respectively. The results for the short-term serum IGFBP-1 yielded CVs for these same respective categories of 8.2%, 16.1%, 29.2% and 13.8%.
CONCLUSIONS
IGFBP-1 measurement was least variable in NGT individuals over both long-term and short-term intervals and variability increased with deteriorating glucose tolerance. Due to its biological variation, IGFBP-1 serum level is more reliable in normal subjects than in individuals with type 2 diabetes.
目的
评估不同糖耐量个体血清胰岛素样生长因子结合蛋白-1（IGFBP-1）的生物学变异。
研究设计与方法
检测了42例空腹受试者的IGFBP-1，这些受试者包括：糖耐量正常（NGT = 15例）、空腹血糖受损（IFG = 9例）、糖耐量受损（IGT = 9例）和2型糖尿病患者（DM = 9例）。测定了IGFBP-1的短期和长期重复性。
结果
NGT、IFG、IGT和DM受试者血清IGFBP-1的长期重复性（CV）分别为20.9%、29.5%、33.1%和48.0%。短期血清IGFBP-1的相应类别CV分别为8.2%、16.1%、29.2%和13.8%。
结论
在长期和短期时间间隔内，NGT个体中IGFBP-1的测量变异最小，且随着糖耐量恶化变异增加。由于其生物学变异，IGFBP-1血清水平在正常受试者中比在2型糖尿病患者中更可靠。
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