Department of Pathology, King Khalid National Guard Hospital, Jeddah, Saudi Arabia.
BMC Med Res Methodol. 2011 Nov 23;11:158. doi: 10.1186/1471-2288-11-158.
Insulin resistance is one of the major aggravating factors for metabolic syndrome. There are many methods available for estimation of insulin resistance which range from complex techniques down to simple indices. For all methods of assessing insulin resistance it is essential that their validity and reliability is established before using them as investigations. The reference techniques of hyperinsulinaemic euglycaemic clamp and its alternative the frequently sampled intravenous glucose tolerance test are the most reliable methods available for estimating insulin resistance. However, many simple methods, from which indices can be derived, have been assessed and validated e.g. homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI). Given the increasing number of simple indices of IR it may be difficult for clinicians and researchers to select the most appropriate index for their studies. This review therefore provides guidelines and advices which must be considered before proceeding with a study.
胰岛素抵抗是代谢综合征的主要加重因素之一。有许多方法可用于估计胰岛素抵抗，范围从复杂的技术到简单的指标。对于评估胰岛素抵抗的所有方法，在将其用作研究之前，必须确定其有效性和可靠性。评估胰岛素抵抗的最可靠方法是高胰岛素正葡萄糖钳夹及其替代的频繁采样静脉葡萄糖耐量试验的参考技术。然而，已经评估和验证了许多简单的方法，例如，稳态模型评估（HOMA），定量胰岛素敏感性检查指数（QUICKI）。鉴于越来越多的简单胰岛素抵抗指数，临床医生和研究人员可能难以为他们的研究选择最合适的指数。因此，本综述提供了在进行研究之前必须考虑的指南和建议。
