Garavello Werner, Romagnoli Marco, Gaini Renato Maria
Department of Otorhinolaryngology-Head and Neck Surgery, Ospedale San Gerardo, University of Milano-Bicocca, DNTB Monza, Italy.
J Pediatr. 2009 Aug;155(2):250-3. doi: 10.1016/j.jpeds.2009.02.038. Epub 2009 May 21.
To evaluate whether adenotonsillectomy leads to complete resolution in children with PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis) syndrome.
Thirty-nine children with PFAPA syndrome were randomized to either adenotonsillectomy (surgery group; n = 19) or expectant management (control group; n = 20). All patients were then invited prospectively to record all PFAPA episodes, and were evaluated clinically every 3 months for 18 months after randomization.
The proportion of patients experiencing complete resolution was 63% in the surgery group and 5% in the control group (P < .001). The mean (+/- standard deviation) number of episodes recorded during the study period was 0.7 +/- 1.2 in the surgery group and 8.1 +/- 3.9 in the control group (P < .001). The episodes were less severe in the surgery group.
Adenotonsillectomy is an effective treatment strategy for children with PFAPA syndrome.
评估腺样体扁桃体切除术是否能使周期性发热、口疮性口炎、咽炎和颈淋巴结炎（PFAPA）综合征患儿完全康复。
39例PFAPA综合征患儿被随机分为两组，一组接受腺样体扁桃体切除术（手术组，n = 19），另一组接受观察等待处理（对照组，n = 20）。随后前瞻性邀请所有患者记录所有PFAPA发作情况，并在随机分组后18个月内每3个月进行一次临床评估。
手术组完全康复的患者比例为63%，而对照组为5%（P <.001）。研究期间记录的发作次数平均值（±标准差），手术组为0.7±1.2次，对照组为8.1±3.9次（P <.001）。手术组发作程度较轻。
腺样体扁桃体切除术是治疗PFAPA综合征患儿的有效策略。
