Piris Adriano, Mihm Martin C
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Warren 820, Boston, MA 02114, USA.
Hematol Oncol Clin North Am. 2009 Jun;23(3):467-80, viii. doi: 10.1016/j.hoc.2009.03.012.
This article reviews the main aspects of the histopathology of cutaneous melanoma with emphasis on recent advances in the morphological evaluation of these lesions. The limitations of morphology for the "so called" borderline lesions are briefly discussed, with a list of diagnostic criteria to help predict behavior for these challenging lesions. The prognostic factors are described with emphasis on the ones that are currently being used by the American Joint Committee on Cancer staging system. Ancillary tests, such as immunohistochemistry and molecular techniques, are also briefly touched upon as complimentary tools to help understand the biology of malignant melanoma. The conclusion is that an accurate morphological evaluation remains the most efficient approach to establish the diagnosis and predict behavior of this challenging neoplasm.
本文回顾了皮肤黑色素瘤组织病理学的主要方面，重点是这些病变形态学评估的最新进展。简要讨论了形态学对“所谓的”临界病变的局限性，并列出了诊断标准，以帮助预测这些具有挑战性病变的行为。描述了预后因素，重点是美国癌症联合委员会分期系统目前使用的因素。还简要提及了辅助检查，如免疫组织化学和分子技术，作为有助于理解恶性黑色素瘤生物学的补充工具。结论是，准确的形态学评估仍然是建立这种具有挑战性肿瘤的诊断和预测其行为的最有效方法。
