Hagan M M, Moss D E
Department of Psychology, University of Texas, El Paso 79968-0553.
Pharmacol Biochem Behav. 1991 Jun;39(2):421-2. doi: 10.1016/0091-3057(91)90201-c.
A group of female rats was deprived and maintained at 75-80% of body weight at three different times during development. Following recovery to normal weight, food intake was measured with and without butorphanol tartrate, a kappa-sigma agonist, 8 mg/kg SC. Animals with a history of deprivation (DEP) showed an increase in postrecovery feeding when they were tested at normal body weight and not food deprived. More importantly, butorphanol prolonged food intake in the 3-h eating test only in the rats with a developmental history of food restriction. A developmental history of fasting in eating disorders may trigger changes in opiate systems that result in atypical feeding behavior in the adult.
一组雌性大鼠在发育过程中的三个不同时间被限制进食并维持在体重的75 - 80%。恢复到正常体重后，分别在给予和不给予8 mg/kg皮下注射酒石酸布托啡诺（一种κ-σ激动剂）的情况下测量食物摄入量。有禁食史的动物（DEP）在体重正常且未处于食物剥夺状态时接受测试，恢复进食后食量增加。更重要的是，仅在有食物限制发育史的大鼠中，布托啡诺在3小时进食试验中延长了食物摄入量。饮食失调中禁食的发育史可能会引发阿片系统的变化，从而导致成年期出现非典型的进食行为。
