Tuthill Mark, Chen Frederick, Paston Samantha, De La Peña Hugo, Rusakiewicz Sylvie, Madrigal Alejandro
The Anthony Nolan Research Institute, Royal Free Hospital, London, UK.
Cancer Immunol Immunother. 2009 Sep;58(9):1481-8. doi: 10.1007/s00262-009-0722-7. Epub 2009 May 23.
Allogeneic haematopoietic stem cell transplantation (HSCT) is an intensive medical treatment involving myeloablative chemo-radiotherapy followed by stem cell rescue using allogeneic haematopoietic stem cells harvested from HLA-matched donors, which is primarily used for the treatment of haematological malignancies. Cytomegalovirus (CMV) infection is one of the major causes of morbidity and death after HSCT. This focused research review highlights the advances made with research into CMV in the HSCT setting. It provides the reader with an overview of current CMV research into the prevention and management of CMV infection.
异基因造血干细胞移植(HSCT)是一种强化医疗手段,包括清髓性放化疗,随后使用从 HLA 匹配供体采集的异基因造血干细胞进行干细胞救援,主要用于治疗血液系统恶性肿瘤。巨细胞病毒(CMV)感染是 HSCT 后发病和死亡的主要原因之一。这篇重点研究综述突出了 HSCT 背景下 CMV 研究取得的进展。它为读者提供了当前 CMV 预防和管理研究的概述。