Su Vivian, Lau Alan F
Natural Products and Cancer Biology Program, Cancer Research Center, University of Hawaii at Manoa, Honolulu, HI 96813, USA.
Cell Mol Life Sci. 2009 Sep;66(17):2819-33. doi: 10.1007/s00018-009-0048-9. Epub 2009 May 26.
The ubiquitin-proteasome pathway of protein degradation is one of the major mechanisms that are involved in the maintenance of the proper levels of cellular proteins. The regulation of proteasomal degradation thus ensures proper cell functions. The family of proteins containing ubiquitin-like (UbL) and ubiquitin-associated (UBA) domains has been implicated in proteasomal degradation. UbL-UBA domain containing proteins associate with substrates destined for degradation as well as with subunits of the proteasome, thus regulating the proper turnover of proteins.
蛋白质降解的泛素-蛋白酶体途径是参与维持细胞内蛋白质适当水平的主要机制之一。因此，蛋白酶体降解的调节确保了细胞功能的正常运行。含有类泛素（UbL）和泛素相关（UBA）结构域的蛋白质家族与蛋白酶体降解有关。含有UbL-UBA结构域的蛋白质与注定要被降解的底物以及蛋白酶体的亚基结合，从而调节蛋白质的正常周转。
