Chen Zhi-Shui, Meng Fan-Ying, Chen Xiao-Ping, Liu Dun-Gui, Wei Lai, Jiang Ji-Pin, Du Dun-Feng, Zhang Wei-Jie, Ming Chang-Sheng, Gong Nian-Qiao
Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
World J Gastroenterol. 2009 May 28;15(20):2552-5. doi: 10.3748/wjg.15.2552.
Combined en bloc liver/pancreas transplantation (CLPT) was used primarily in the treatment of otherwise non-resectable upper abdominal malignancy. In fact, a more appropriate indication is in patients with liver disease and insulin-dependent diabetes mellitus (IDDM). Here, we report on two successful cases of CLPT at our hospital. One was a patient with non-resectable advanced liver cancer. The recipient survived for 23 mo and finally died of recurrent tumor. The other was a patient with severe biliary complication after orthotopic liver transplantation and preoperative IDDM. We performed CLPT with a modified surgical technique of preserving the native pancreas. He is currently liver-disease- and insulin-free more than 27 mo post-transplant. Based on our experience in two cases of abdominal cluster transplantation, we describe the technical details of CLPT and a modification of the surgical procedure.
整块肝脏/胰腺联合移植（CLPT）主要用于治疗其他方法无法切除的上腹部恶性肿瘤。事实上，更合适的适应证是患有肝病和胰岛素依赖型糖尿病（IDDM）的患者。在此，我们报告我院两例CLPT成功病例。一例是患有无法切除的晚期肝癌患者。受者存活了23个月，最终死于肿瘤复发。另一例是原位肝移植术后出现严重胆道并发症且术前患有IDDM的患者。我们采用保留自身胰腺的改良手术技术进行了CLPT。他目前在移植后超过27个月无肝病且无需胰岛素治疗。基于我们在两例腹部联合移植病例中的经验，我们描述了CLPT的技术细节及手术方法的改良。
