Head of Mutagenicity, Toxicol Laboratories Limited, Bromyard Road, Ledbury HR8 1LG, Herefordshire, U.K.
Int J Cosmet Sci. 1983 Apr;5(2):51-71. doi: 10.1111/j.1467-2494.1983.tb00326.x.
Synopsis A number of the constituents of semi-permanent and permanent hair dyes have been shown to be mutagenic in bacteria, to induce mutation, chromosome breakage, sister chromatid exchanges and malignant transformation in mammalian cells, to cause mutation in Drosophila, to induce mitotic recombination in yeast and to induce tumours in rodents. Some hair dye ingredients and commercial dyes have been shown to give rise, in the urine of treated rats, to metabolites which are also mutagenic in bacteria. The test systems used are briefly described and the data generated are reviewed. In addition, attempts to identify whether the hazards predicted from the laboratory studies present a risk to man either by epidemiological studies or monitoring of exposed populations are also discussed.
概要 半永久性和永久性染发剂的一些成分已被证明在细菌中具有致突变性，可在哺乳动物细胞中诱导突变、染色体断裂、姐妹染色单体交换和恶性转化，在果蝇中引起突变，在酵母中诱导有丝分裂重组，并在啮齿动物中诱导肿瘤。一些染发剂成分和商业染发剂已被证明会在接受治疗的大鼠尿液中产生代谢物，这些代谢物在细菌中也具有致突变性。简要描述了所使用的测试系统，并审查了所产生的数据。此外，还讨论了是否可以通过流行病学研究或监测暴露人群来识别实验室研究预测的危害是否对人类构成风险。
