Colgate-Palmolive Ltd., Research and Development Department, Ordsall Lane, Salford, Lanes.
Int J Cosmet Sci. 1983 Jun;5(3):77-84. doi: 10.1111/j.1467-2494.1983.tb00329.x.
Synopsis Greasy hair is a common problem in Europe. The first step in developing anti-grease hair products must be to establish a sensitive protocol for measuring any changes in perceived hair greasiness. Sensitive clinical trials and in vivo evaluation methods of determining hair greasiness have been developed that show significant differences in the perceived hair greasiness following the use of different shampoos. Products tested in two clinical trials for efficacy as anti-grease shampoos were an anti-grease shampoo containing 2% 3,4-thiolanediol as the active ingredient, and a baby shampoo based on mild surfactants. The same placebo shampoo based on ether sulphates used in typical European shampoo formulations was used in both tests. A shampoo containing 2% zinc pyrithione was included in the trials as a control, since there were indications that this would increase the amount of hair greasiness. Neither of the test products were shown to be effective anti-grease shampoos. The shampoo containing 2% zinc pyrithione was shown to produce significantly more greasiness than both the placebo and the test shampoos. Since significant differences could be shown between the different shampoos, the protocol and in vivo evaluation techniques used in these clinical trials are considered to be validated.
摘要 油性头发在欧洲是一个常见的问题。开发抗油性头发产品的第一步必须建立一个敏感的协议，以测量任何感知头发油腻度的变化。已经开发出敏感的临床试验和体内评估方法来确定头发的油腻度，这些方法显示出使用不同洗发水后感知头发油腻度的显著差异。在两项临床试验中，含有 2%3,4-硫代二丙醇的抗油脂洗发水和基于温和表面活性剂的婴儿洗发水被测试为有效的抗油脂洗发水。在这两项测试中，都使用了基于醚硫酸盐的相同安慰剂洗发水，这是典型的欧洲洗发水配方中使用的。试验中还包括含有 2%吡啶硫酮锌的洗发水作为对照，因为有迹象表明这会增加头发的油腻度。这两种测试产品都没有表现出有效的抗油脂洗发水的功效。含有 2%吡啶硫酮锌的洗发水比安慰剂和测试洗发水产生的油腻感都明显更严重。由于不同洗发水之间可以显示出显著的差异，因此这些临床试验中使用的方案和体内评估技术被认为是有效的。
