Dermatology Department, Medical Faculty, Uludag University, Bursa, Turkey.
J Eur Acad Dermatol Venereol. 2009 Dec;23(12):1432-4. doi: 10.1111/j.1468-3083.2009.03226.x. Epub 2009 Mar 17.
Pemphigus is a chronic immunobullous disease, characterized by formation of blisters and erosions in skin and/or mucous membranes. This severe disease requires systemic immunosuppressive therapy. However, some patients are refractory, and long-term use of immunosuppressive agents can cause serious side-effects. Mycophenolic acid is increasingly being used as a corticosteroid-sparing agent or as monotherapy in immunosuppressive regimens.
We aimed to evaluate the effectiveness of mycophenolate sodium, a sodium salt of mycophenolic acid, in the treatment of pemphigus vulgaris.
Six patients who were diagnosed as pemphigus vulgaris with active, refractory disease were treated with mycophenolate sodium. Three patients received mycophenolate sodium monotherapy; three patients received mycophenolate in combination with steroid. All patients were monitored regularly.
Mycophenolate sodium was well tolerated with a similar efficacy of mycophenolate mofetil, and no side-effects have been observed.
Mycophenolate sodium appears to be an effective and safe alternative in the treatment of pemphigus vulgaris.
天疱疮是一种慢性免疫性大疱病，其特征为皮肤和/或黏膜形成水疱和糜烂。这种严重的疾病需要全身免疫抑制治疗。然而，一些患者是难治性的，长期使用免疫抑制剂会导致严重的副作用。霉酚酸酯越来越多地被用作皮质类固醇的节省剂或免疫抑制方案中的单药治疗。
我们旨在评估霉酚酸钠（霉酚酸的钠盐）在治疗寻常型天疱疮中的疗效。
6 名被诊断为寻常型天疱疮且疾病活动、难治的患者接受了霉酚酸钠治疗。3 名患者接受霉酚酸钠单药治疗；3 名患者接受霉酚酸酯联合类固醇治疗。所有患者均定期监测。
霉酚酸钠耐受性良好，与霉酚酸酯的疗效相似，未观察到不良反应。
霉酚酸钠似乎是治疗寻常型天疱疮的一种有效且安全的替代药物。
Zotero 插件