Hiratsuka J, Fukuda H, Kobayashi T, Karashima H, Yoshino K, Imajo Y, Mishima Y
Department of Radiation Oncology, Kawasaki Medical School, Kurashiki, Japan.
Radiat Res. 1991 Nov;128(2):186-91.
The relative biological effectiveness (RBE) of 10B-neutron capture therapy (BNCT) on skin was analyzed using hamsters. The Kyoto University Research Reactor, which has a very low contamination of gamma rays and fast neutrons, was used as a thermal neutron source. Boron-10-para-boronophenylalanine hydrochloride ([10B]BPA.HCl) was administered to the hamsters. The evolution and time course of early skin reactions were assessed. These reactions were compared with those produced by electron beams. The maximum safe skin doses (no more than moist desquamation) of BNCT and electron beams were established to be 11 and 21 Gy, respectively. The RBE at this single dose with BNCT was found to be 1.94, assuming that the RBE of the gamma rays was 1.0 and each component of BNCT (mixed radiations) was simply additive.
使用仓鼠分析了硼中子俘获疗法（BNCT）对皮肤的相对生物效应（RBE）。使用京都大学研究堆作为热中子源，该反应堆的γ射线和快中子污染极低。向仓鼠施用硼 - 10 - 对硼苯丙氨酸盐酸盐（[¹⁰B]BPA.HCl）。评估早期皮肤反应的演变和时间进程。将这些反应与电子束产生的反应进行比较。BNCT和电子束的最大安全皮肤剂量（不超过湿性脱屑）分别确定为11 Gy和21 Gy。假设γ射线的RBE为1.0且BNCT的每个成分（混合辐射）简单相加，则发现该单剂量下BNCT的RBE为1.94。
