血液蛋白质和成纤维细胞在多壁碳纳米管上的吸附与黏附
Adsorption and adhesion of blood proteins and fibroblasts on multi-wall carbon nanotubes.
作者信息
Li Dejun, Yuan Li, Yang Ying, Deng Xiangyun, Lü Xiaoying, Huang Yan, Cao Zheng, Liu Hao, Sun Xueliang
机构信息
College of Physics and Electronic Information Science, Tianjin Normal University, Tianjin, 300074, China.
出版信息
Sci China C Life Sci. 2009 May;52(5):479-82. doi: 10.1007/s11427-009-0049-9. Epub 2009 May 27.
This article concerns the investigation of blood protein adsorption on carbon paper and multi-wall carbon nanotubes (MWCNTs). Mouse fibroblast cell adhesion and growth on MWCNTs was also studied. The results showed that fibrinogen adsorption on carbon paper was much lower than that on MWCNTs, which means that platelets readily aggregate on the surface of MWCNTs. Mouse fibroblast cells implanted on MWCNTs tended to grow more prolifically than those implanted on carbon paper. The cell concentration observed on MWCNTs increased from 1.2x10(5)/mL for a single day culture to 2x10(5)/mL for a 7-day culture. No toxicity reaction was observed during the culturing period. These results indicated that MWCNTs possessed excellent tissue compatibility.
本文涉及对碳纸和多壁碳纳米管（MWCNTs）上血液蛋白质吸附的研究。还研究了小鼠成纤维细胞在MWCNTs上的黏附与生长情况。结果表明，纤维蛋白原在碳纸上的吸附量远低于在MWCNTs上的吸附量，这意味着血小板易于在MWCNTs表面聚集。植入MWCNTs上的小鼠成纤维细胞比植入碳纸上的细胞生长得更旺盛。在MWCNTs上观察到的细胞浓度从单日培养的1.2×10⁵/mL增加到7日培养的2×10⁵/mL。在培养期间未观察到毒性反应。这些结果表明MWCNTs具有优异的组织相容性。
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