通过基于肌酐和胱抑素C的不同方程评估神经性厌食症患者的肾小球滤过率。
Estimation of GFR by different creatinine- and cystatin-C-based equations in anorexia nervosa.
作者信息
Delanaye P, Cavalier E, Radermecker R P, Paquot N, Depas G, Chapelle J-P, Scheen A J, Krzesinski J-M
机构信息
Department of Nephrology-Dialysis, University of Liège, CHU Sart Tilman, Liège, Belgium.
出版信息
Clin Nephrol. 2009 May;71(5):482-91. doi: 10.5414/cnp71482.
BACKGROUND
Patients with anorexia nervosa (AN) are at high risk of renal failure. Glomerular filtration rate (GFR) is overestimated when estimated by the creatinine-based equations. We have studied the accuracy and precision of cystatin C-based equations.
METHOD
27 AN patients were included. GFR was measured with the chromium-51-ethylenediaminetetraacetate (51Cr-EDTA) method. We have compared the accuracy and precision of creatinine-based equations (MDRD and Cockcroft) with those of different new cystatin C-based equations.
RESULTS
The creatinine-based equations overestimate measured GFR, especially the MDRD study equation. All the cystatin C-based equations also overestimate measured GFR. The Cockcroft and Gault formula and the cystatin C-based equation published by Rule have the best accuracy and precision, but these last performances remain unsatisfactory.
CONCLUSION
Both creatinine and cystatin C-based equations strongly overestimate measured in patients with AN.
背景
神经性厌食症（AN）患者存在肾衰竭的高风险。当通过基于肌酐的公式估算肾小球滤过率（GFR）时，其值会被高估。我们研究了基于胱抑素C的公式的准确性和精密度。
方法
纳入27例AN患者。采用铬-51-乙二胺四乙酸（51Cr-EDTA）法测量GFR。我们将基于肌酐的公式（MDRD和Cockcroft）的准确性和精密度与不同的基于胱抑素C的新公式进行了比较。
结果
基于肌酐的公式高估了测量的GFR，尤其是MDRD研究公式。所有基于胱抑素C的公式也高估了测量的GFR。Cockcroft和Gault公式以及Rule发表的基于胱抑素C的公式具有最佳的准确性和精密度，但这些最后的表现仍然不尽人意。
结论
基于肌酐和胱抑素C的公式都严重高估了AN患者测量的结果。
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