Sugawara N, Sugawara C, Sato M, Katakura M, Takahashi H, Mori M
Department of Public Health, Sapporo Medical College, Japan.
Res Commun Chem Pathol Pharmacol. 1991 Jun;72(3):353-62.
In 30- and 80-day-old LEC rats, hepatic Cu and Cu-metallothionein (MT) concentrations were much higher than those in control Fischer rats. The gross deposition was accompanied with enhancements of Zn and Fe concentrations. In LEC rats, more than half of the hepatic Cu was located in the cytosol fraction. Most of cytosolic Cu was bound to MT. In organs other than the liver, sharp depositions of Cu were not found. Both groups of LEC rats showed significantly low serum Cu concentrations and ceruloplasmin activity. The great accumulation of hepatic Cu with the increase of age is due to the inherent depression of the release of Cu from the liver. The deposition may be closely related to the onset of the sudden hepatitis observed in LEC rats.
在30日龄和80日龄的LEC大鼠中，肝脏铜及铜结合金属硫蛋白（MT）的浓度远高于对照的Fischer大鼠。这种大量沉积伴随着锌和铁浓度的升高。在LEC大鼠中，超过一半的肝脏铜位于胞质部分。大部分胞质铜与MT结合。在肝脏以外的器官中，未发现铜的明显沉积。两组LEC大鼠的血清铜浓度和铜蓝蛋白活性均显著降低。随着年龄增长肝脏铜的大量蓄积是由于肝脏铜释放的内在抑制。这种沉积可能与LEC大鼠中观察到的突发性肝炎的发病密切相关。
