取代基对砷二硫醇加合物结合常数的影响。
Substituent effects on the binding constants of arsenical-dithiol adducts.
作者信息
Dill K, Huang L H, McGown E L, Youn S H, O'Connor R J
机构信息
Department of Chemistry, Clemson University, SC 29634-1905.
出版信息
Res Commun Chem Pathol Pharmacol. 1991 Jun;72(3):367-70.
PMID:1947439
Abstract
Proton nuclear magnetic resonance spectroscopy (1H NMR) was used to determine the relative binding constants for several arsenical-dithiol adducts. The compounds investigated were 2,3-dimercaptopropanol (British anti-lewisite; BAL), 1,2-ethane dithiol (ET), and 1,2-propane dithiol (PDT). It was found that PDT has a significantly higher affinity than ET or BAL for phenyldichloroarsine (PDA) in methanol.
摘要
质子核磁共振波谱法（1H NMR）用于测定几种砷二硫醇加合物的相对结合常数。所研究的化合物有2,3-二巯基丙醇（英国抗路易氏剂；BAL）、1,2-乙二硫醇（ET）和1,2-丙二硫醇（PDT）。结果发现，在甲醇中，PDT对苯基二氯胂（PDA）的亲和力明显高于ET或BAL。
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