通过核磁共振光谱法测定的砷解毒剂加合物的相对结合常数。

Relative binding constants of arsenical-antidote adducts determined by NMR spectroscopy.

作者信息

O'Connor R J, McGown E L, Dill K, Hallowell S F

机构信息

Biophysical Research Division, Letterman Army Institute of Research, Presidio of San Francisco, CA 94129-6800.

出版信息

Res Commun Chem Pathol Pharmacol. 1990 Sep;69(3):365-8.

PMID:2173085

Abstract

Proton nuclear magnetic resonance spectroscopy was used to determine relative binding constants for several arsenical-antidote adducts. It was found that BAL (2,3-dimercaptopropanol) and DMPS (2,3-dimercaptopropanesulfonic acid) had a higher affinity than DMSA (2,3-dimercaptosuccinic acid) for the two organic arsenicals studied.

摘要

利用质子核磁共振波谱法测定了几种砷解毒剂加合物的相对结合常数。结果发现，在所研究的两种有机砷化合物中，二巯丙醇（BAL）和二巯丙磺酸钠（DMPS）比二巯基丁二酸（DMSA）具有更高的亲和力。