Tamaya T, Sato S, Imai A
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.
Res Commun Chem Pathol Pharmacol. 1991 Sep;73(3):367-70.
Epithelial-stromal interaction was investigated in human endometrial carcinoma. The medium cultured with fibroblasts derived from human endometrial carcinoma tissue increased [3H]thymidine incorporation into and estrogen receptor level of endometrial carcinoma (Hashimoto) cells. Concomitant exposure to estradiol, but not to progesterone, synergistically enhanced the conditioned medium-induced events. These findings demonstrated direct interaction of epithelial cells and its stromal cells in endometrial carcinoma.
在人子宫内膜癌中研究了上皮-间质相互作用。用人子宫内膜癌组织来源的成纤维细胞培养的培养基增加了[3H]胸腺嘧啶核苷掺入子宫内膜癌（桥本）细胞以及其雌激素受体水平。同时暴露于雌二醇而非孕酮可协同增强条件培养基诱导的事件。这些发现证明了子宫内膜癌中上皮细胞与其间质细胞的直接相互作用。
