Bisinotto Flora Margarida Barra, Braz José Reinaldo Cerqueira
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Brazil.
Rev Bras Anestesiol. 2003 Aug;53(4):467-80. doi: 10.1590/s0034-70942003000400006.
Infrarenal aortic cross-clamping is associated to cardiovascular effects. This study aimed at analyzing the effects of halothane, isoflurane and sevoflurane on cardiovascular function of dogs following infrarenal aortic cross-clamping.
Thirty mongrel dogs were randomly divided in three groups, according to equipotent (0.75 MAC) inhaled anesthetic doses: GH (n = 10) - 0.67% halothane; GI (n = 10) - 0.96% isoflurane; and GS (n = 10) - 1.8% sevoflurane. All dogs were submitted to infrarenal aortic cross-clamping for 30 minutes. Hemodynamic parameters were measured at control (C), at 15 (Ao15) and 30 (Ao30) minutes of aortic cross-clamping, and immediately (DAo) and 15 (DAo15) minutes after aortic unclamping.
In all groups, infrarenal aortic cross-clamping significantly increased mean blood pressure, right atrial pressure, cardiac index, stroke volume index, left ventricular work index and right ventricular work index. Pulmonary artery pressure significantly increased during cross-clamping in GI and GS groups while pulmonary capillary wedge pressure significantly increased in GH and GI groups. After aortic unclamping all hemodynamic parameters have returned to control levels with the exception of cardiac and stroke volume indices which remained high, followed by systemic vascular resistance index decrease. There have been no significant differences among groups in studied attributes, except for heart rate which was always lower in GH group as compared to other groups during and after infrarenal aortic cross-clamping.
In dogs under our experimental conditions, equipotent concentrations (0.75 MAC) of inhalational halothane, isoflurane and sevoflurane have not attenuated cardiovascular responses to infrarenal aortic cross-clamping.
肾下主动脉阻断与心血管效应相关。本研究旨在分析氟烷、异氟烷和七氟烷对肾下主动脉阻断后犬心血管功能的影响。
30只杂种犬根据等效（0.75 MAC）吸入麻醉剂量随机分为三组：GH组（n = 10）- 0.67%氟烷；GI组（n = 10）- 0.96%异氟烷；GS组（n = 10）- 1.8%七氟烷。所有犬均接受肾下主动脉阻断30分钟。在对照（C）、主动脉阻断15分钟（Ao15）和30分钟（Ao30）时，以及主动脉松开后即刻（DAo）和15分钟（DAo15）测量血流动力学参数。
在所有组中，肾下主动脉阻断均显著增加平均血压、右心房压力、心脏指数、每搏量指数、左心室作功指数和右心室作功指数。GI组和GS组在阻断期间肺动脉压力显著升高，而GH组和GI组肺毛细血管楔压显著升高。主动脉松开后，除心脏和每搏量指数仍较高外，所有血流动力学参数均恢复至对照水平，随后全身血管阻力指数降低。在所研究的指标中，各组间无显著差异，但在肾下主动脉阻断期间及之后，GH组心率始终低于其他组。
在我们的实验条件下，犬吸入等效浓度（0.75 MAC）的氟烷、异氟烷和七氟烷并未减弱对肾下主动脉阻断的心血管反应。
