Vieira Antonio Mauro, Schnaider Taylor Brandão, Costa Flávio Aparecido, Costa Everaldo Donizeti
CET/SBA do Serviço de Anestesiologia do Hospital de Clínicas da Faculdade de Ciências Médicas da Universidade do Vale do Sapucaí (HC-FCM-UNIVAS), Pouso Alegre, MG.
Rev Bras Anestesiol. 2003 Sep;53(5):586-90.
Epidural clonidine has analgesic properties and potentiates local anesthetic effects; there are, however, some side effects including: arterial hypotension, bradycardia and sedation. This study aimed at evaluating analgesia and sedation of clonidine associated to 0.75% ropivacaine in the postoperative period of open cholecystectomy.
Participated in this study 30 patients of both genders, aged 18 to 50 years, weighing 50 to 100 kg, physical status ASA I or II, submitted to cholecystectomy, who were distributed in two groups: Control Group (CG) received 0.75% ropivacaine (20 ml) with saline solution (1 ml); Experimental Group (EG) received 0.75% ropivacaine (20 ml) with clonidine (1 ml = 150 microg). Analgesia and sedation were observed at 2, 6 and 24 postoperative hours.
Mean age was 41 yr in CG and 37 yr in EG. Mean weight was 67 kg in CG and 64 kg to EG. Postoperative sedation was significantly higher at 2 and 6 hours in the Experimental Group. Analgesia was observed in more EG patients as compared to Control Group.
The association of clonidine and ropivacaine has produced longer analgesia and sedation at 2 and 6 hours of observation.
硬膜外可乐定具有镇痛作用，并能增强局部麻醉效果；然而，它也存在一些副作用，包括动脉低血压、心动过缓和镇静作用。本研究旨在评估可乐定与0.75%罗哌卡因联合应用于开腹胆囊切除术后镇痛和镇静效果。
本研究纳入30例年龄在18至50岁之间、体重50至100 kg、美国麻醉医师协会（ASA）身体状况分级为I或II级、接受胆囊切除术的患者，分为两组：对照组（CG）接受0.75%罗哌卡因（20 ml）加生理盐水（1 ml）；实验组（EG）接受0.75%罗哌卡因（20 ml）加可乐定（1 ml = 150 μg）。术后2、6和24小时观察镇痛和镇静情况。
对照组平均年龄为41岁，实验组为37岁。对照组平均体重为67 kg，实验组为64 kg。实验组术后2小时和6小时的镇静程度明显更高。与对照组相比，实验组有更多患者出现镇痛效果。
可乐定与罗哌卡因联合应用在观察的2小时和6小时产生了更长时间的镇痛和镇静效果。
