淋巴结阴性胃癌患者中淋巴管侵犯的预后影响

Prognostic impact of lymphatic invasion in patients with node-negative gastric cancer.

作者信息

Ichikawa Daisuke, Kubota Takeshi, Kikuchi Shojiro, Fujiwara Hitoshi, Konishi Hirotaka, Tsujiura Masahiro, Ikoma Hisashi, Nakanishi Masayoshi, Okamoto Kazuma, Sakakura Chohei, Ochiai Toshiya, Kokuba Yukihito, Otsuji Eigo

机构信息

Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.

出版信息

J Surg Oncol. 2009 Aug 1;100(2):111-4. doi: 10.1002/jso.21311.

DOI:10.1002/jso.21311

PMID:19475584

Abstract

BACKGROUND AND OBJECTIVES

This study investigated the prognostic impact of lymphatic invasion on the outcome of patients with node-negative gastric cancer.

METHODS

A total of 828 patients with node-negative gastric cancer who underwent curative gastrectomy were reviewed retrospectively. The clinicopathological features and prognoses of patients with lymphatic invasion were compared to those of patients without such invasion.

RESULTS

The total rate of lymphatic invasion was 18.2% in node-negative gastric cancers, with a significant difference between early gastric cancers (9.8%) and advanced gastric cancers (49.2%). The presence of lymphatic invasion correlated significantly with tumor location, size and depth of tumor (P < 0.01). Lymphatic invasion was significantly associated with a poorer overall survival in node-negative gastric cancer patients on univariate analysis (P < 0.001) as well as multivariate analysis (P < 0.01).

CONCLUSIONS

Lymphatic invasion provides additional useful information that could be applied to identify patients at high risk for recurrence who might be candidates for adjuvant therapies in patients with node-negative gastric cancers.

摘要

背景与目的

本研究调查了淋巴血管侵犯对淋巴结阴性胃癌患者预后的影响。

方法

回顾性分析了828例行根治性胃切除术的淋巴结阴性胃癌患者。比较了有淋巴血管侵犯患者与无淋巴血管侵犯患者的临床病理特征及预后。

结果

淋巴结阴性胃癌患者的淋巴血管侵犯总发生率为18.2%，早期胃癌（9.8%）与进展期胃癌（49.2%）之间存在显著差异。淋巴血管侵犯的存在与肿瘤位置、大小及肿瘤浸润深度显著相关（P < 0.01）。单因素分析（P < 0.001）及多因素分析（P < 0.01）均显示，淋巴血管侵犯与淋巴结阴性胃癌患者较差的总生存期显著相关。