Dahm Jamie Lyn, Cook Elaina, Baugh Kaylene, Wileyto E Paul, Pinto Angela, Leone Frank, Halbert Chanita Hughes, Schnoll Robert A
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
J Natl Med Assoc. 2009 May;101(5):450-5. doi: 10.1016/s0027-9684(15)30931-7.
A fraction of smokers considered eligible for pharmacotherapy treatment trials for nicotine dependence enrolled. Little is known about smokers not enrolling in a treatment trial or how these smokers differ from those who have enrolled.
We screened 2257 individuals for a smoking cessation trial involving behavioral counseling and a novel medication.
Of those screened, 33% of callers were eligible for enrollment (N=753). Of those eligible for the trial, 37% attended the subsequent enrollment session (N=282). We compared the 282 attendees to the 471 smokers who were eligible for the trial but did not attend. Logistic regression indicated that African American smokers were about half as likely to enroll in the trial (odds ratio [OR], 0.55; 95% CI, 0.36-0.84); for every year increase in age, participants were 4% more likely to enroll (OR, 1.04; 95% CI, 1.02-1.06); and participants who were motivated to enroll in the trial for financial incentives were 42% less likely to enroll in the trial (OR, 0.58; 95% CI, 0.45-0.76).
These findings suggest the need to devise and test recruitment strategies directed toward African Americans and younger smokers to increase enrollment among eligible smokers to smoking cessation treatment trials.
在符合尼古丁依赖药物治疗试验条件的吸烟者中，仅有一部分人参与了试验。对于未参与治疗试验的吸烟者以及这些吸烟者与参与试验者之间的差异，我们知之甚少。
我们对2257名个体进行了戒烟试验筛查，该试验包括行为咨询和一种新型药物。
在接受筛查的人群中，33%的来电者符合入选条件（N = 753）。在符合试验条件的人群中，37%参加了后续的入选环节（N = 282）。我们将这282名参与者与471名符合试验条件但未参加的吸烟者进行了比较。逻辑回归分析表明，非裔美国吸烟者参与试验的可能性约为一半（优势比[OR]，0.55；95%置信区间，0.36 - 0.84）；年龄每增加一岁，参与者参与试验的可能性增加4%（OR，1.04；95%置信区间，1.02 - 1.06）；因经济激励而有动力参与试验的参与者参与试验的可能性降低42%（OR，0.58；95%置信区间，0.45 - 0.76）。
这些发现表明，需要设计并测试针对非裔美国人和年轻吸烟者的招募策略，以增加符合条件的吸烟者参与戒烟治疗试验的人数。
