Ferguson Sherry A, Boctor Sherin Y
Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA.
J Am Assoc Lab Anim Sci. 2009 May;48(3):292-5.
Many laboratory studies require oral administration of drugs. Dietary administration in food or water is useful, but is not always the best method. Orogastric gavage can be stressful. Here, we describe in detail a relatively stress-free technique that can be applied to multiple daily administrations using a palatable food item. This method was successfully used to administer water or methylphenidate 3 times daily to young pair-housed adolescent rats.
许多实验室研究需要口服给药。通过食物或水进行饮食给药是有用的,但并不总是最佳方法。经口胃管灌喂可能会造成压力。在此,我们详细描述一种相对无压力的技术,该技术可使用可口的食物用于多次每日给药。此方法已成功用于每日3次给成对饲养的幼年青春期大鼠喂水或哌醋甲酯。