Department of Cardiothoracic Surgery, Cardiac and Vascular Sciences, St. George's Hospital, University of London, London, UK.
Eur J Cardiothorac Surg. 2009 Sep;36(3):563-71. doi: 10.1016/j.ejcts.2009.04.002. Epub 2009 May 24.
Considerable research efforts have recently been made towards the application of autologous stem cell therapy for cardiovascular regeneration. Patients with coronary artery disease undergoing surgery represent a potential target. As yet, this approach has failed to obtain satisfactory evidence in clinical studies. However, several observational studies have described mobilising effect of cardiac surgery on endogenous stem cells, although the mechanisms of this phenomenon and its clinical relevance are not defined. This article reviews available clinical data on the effect of cardiac surgery on endogenous stem cells and outlines some of the controversies in this area.
最近，人们在将自体干细胞疗法应用于心血管再生方面进行了大量研究。接受手术的冠心病患者是潜在的目标人群。然而，这种方法在临床研究中尚未获得令人满意的证据。但是，一些观察性研究已经描述了心脏手术对内源性干细胞的动员作用，尽管这种现象的机制及其临床相关性尚不清楚。本文综述了心脏手术对内源性干细胞影响的现有临床数据，并概述了该领域的一些争议。
