Li Zhi Gang, Qian De Ying, Cen Jian Min, Chen Guan Di, Shu Yan Hong
Department of Gynecology and Obstetrics, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Int J Gynaecol Obstet. 2009 Sep;106(3):202-5. doi: 10.1016/j.ijgo.2009.04.011. Epub 2009 May 27.
To investigate the frequency of cervical intraepithelial neoplasia (CIN) 2 or greater in women with high-grade squamous intraepithelial lesion (HSIL), and to evaluate whether colposcopically-directed biopsy is a necessary procedure for managing HSIL in a low-resource country.
A retrospective review was undertaken of women with HSIL on a Pap smear.
Of 348 women who had undergone colposcopically-directed biopsies and loop electrosurgical excisional procedure (LEEP), 321 (92.2%) had CIN 2 or greater. Of these, 279 were diagnosed with CIN 2 or greater on biopsy as were 264 on LEEP. The lesions in women who had CIN 2, satisfactory colposcopy, and more biopsies were more likely to be completely excised by biopsy. The mean length of time between the initial Pap smear and LEEP was significantly longer than between the initial Pap smear and biopsy.
Women with HSIL can be effectively managed using the see-and-treat approach in a low-resource country owing to the frequency of CIN 2 or greater.
调查高级别鳞状上皮内病变（HSIL）女性中宫颈上皮内瘤变（CIN）2级或更高等级的发生率，并评估在资源匮乏国家，阴道镜引导下活检对于管理HSIL是否为必要步骤。
对巴氏涂片显示为HSIL的女性进行回顾性研究。
在348例接受了阴道镜引导下活检及环形电切术（LEEP）的女性中，321例（92.2%）患有CIN 2级或更高等级。其中，279例活检诊断为CIN 2级或更高等级，264例LEEP诊断为CIN 2级或更高等级。CIN 2级、阴道镜检查满意且活检次数更多的女性病变更有可能通过活检完全切除。初次巴氏涂片至LEEP的平均时间显著长于初次巴氏涂片至活检的时间。
由于CIN 2级或更高等级的发生率，在资源匮乏国家，HSIL女性可采用即诊即治方法进行有效管理。
