Gautvik K M
Institute of Medical Biochemistry, University of Oslo, Norway.
Scand J Clin Lab Invest Suppl. 1991;206:85-92.
Medullary carcinoma of the thyroid gland (MCT) is a disease which shows an early tendency to spread both locally as well as by the blood stream. It is to day possible to make an early diagnosis in patients who have the familial form of the disease as well as perform an organ specific localization regarding possible spread of the disease. Calcitonin is a major product of MCT cells and represent the most used tumour marker for diagnosis and evaluation of prognosis. Basal calcitonin levels are not suited for making neither an accurate diagnostic or prognostic evaluation. Calcitonin provocation test (pentagastrin injections, calcium infusion/injection or a combination) are recommended for both early diagnosis as well as follow-up studies for mapping of the extent of disease. An early diagnosis can be made in kindred of a patient with familial MCT. Selective venous catheterization will in a significant way aid the localization of the disease, and together with calcitonin provocation tests reveal the presence of micro-metastases.
甲状腺髓样癌（MCT）是一种疾病，其早期就有局部扩散以及通过血流扩散的倾向。如今，对于患有家族性形式该疾病的患者，既能够进行早期诊断，也能够针对疾病可能的扩散进行器官特异性定位。降钙素是MCT细胞的主要产物，是诊断和评估预后最常用的肿瘤标志物。基础降钙素水平既不适合进行准确的诊断评估，也不适合进行预后评估。推荐进行降钙素激发试验（注射五肽胃泌素、输注/注射钙或两者结合）用于早期诊断以及疾病范围测绘的随访研究。对于患有家族性MCT患者的亲属，可以进行早期诊断。选择性静脉插管将在很大程度上有助于疾病的定位，并与降钙素激发试验一起揭示微转移的存在。
